Research Team | Research Team

Ying Xu (徐璎), Professor

Director of CAM-SU Genomic Resource Center, 2014-Present
Distinguished Professor, Soochow University, 2014-Present
Distinguished Professor, Model Animal Research Center, Nanjing University, 2006-Present
Postdoctoral Fellow, University of California, San Francisco, 2003-2006
Ph.D., University of Tokyo, 2001
Email: yingxu@suda.edu.cn

RESEARCH INTERESTS

Organisms have adapted to the potent pressures of day-night changes in our environment with daily anticipatory changes in physiology and behavioral. My laboratory is using cellular, molecular, genetic, evolutional and behavioral approaches to understand the mechanism that drive circadian rhythms in the brain and peripheral tissues and how our daily schedules can disrupt these reliable changes in metabolism, gene expression, hormone levels and behavior, and result in diseases.

SELECTED PUBLICATIONS

Xing L, An Y, Shi G, Yan J, Xie P, Qu Z, Zhang Z, Liu Z, Pan D, Xu Y (2017) Correlated evolution between CK1delta Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. The Journal of biological chemistry 292: 161-171

Zhang L, Hirano A, Hsu PK, Jones CR, Sakai N, Okuro M, McMahon T, Yamazaki M, Xu Y, Saigoh N, Saigoh K, Lin ST, Kaasik K, Nishino S, Ptacek LJ, Fu YH (2016) A PERIOD3 variant causes a circadian phenotype and is associated with a seasonal mood trait. Proceedings of the National Academy of Sciences of the United States of America 113: E1536-1544

Shi G, Xie P, Qu Z, Zhang Z, Dong Z, An Y, Xing L, Liu Z, Dong Y, Xu G, Yang L, Liu Y, Xu Y (2016) Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for Clock Function. Cell Rep 14: 823-834

Qu Z, Zhang H, Huang M, Shi G, Liu Z, Xie P, Li H, Wang W, Xu G, Zhang Y, Yang L, Huang G, Takahashi JS, Zhang WJ, Xu Y (2016) Loss of ZBTB20 impairs circadian output and leads to unimodal behavioral rhythms. Elife 5

Hirano A, Shi G, Jones CR, Lipzen A, Pennacchio LA, Xu Y, Hallows WC, McMahon T, Yamazaki M, Ptacek LJ, Fu YH (2016) A Cryptochrome 2 mutation yields advanced sleep phase in humans. Elife 5

Dong Z, Huang M, Liu Z, Xie P, Dong Y, Wu X, Qu Z, Shen B, Huang X, Zhang T, Li J, Liu J, Yanase T, Zhou C, Xu Y (2016) Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell death and differentiation 23: 1602-1614

Shi G, Xing L, Liu Z, Qu Z, Wu X, Dong Z, Wang X, Gao X, Huang M, Yan J, Yang L, Liu Y, Ptacek LJ, Xu Y (2013) Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proceedings of the National Academy of Sciences of the United States of America 110: 4750-4755

Liu Z, Huang M, Wu X, Shi G, Xing L, Dong Z, Qu Z, Yan J, Yang L, Panda S, Xu Y (2014) PER1 phosphorylation specifies feeding rhythm in mice. Cell Rep 7: 1509-1520

Yan J, Shi G, Zhang Z, Wu X, Liu Z, Xing L, Qu Z, Dong Z, Yang L, Xu Y (2014) An intensity ratio of interlocking loops determines circadian period length. Nucleic acids research 42: 10278-10287

Shi G, Xing L, Liu Z, Qu Z, Wu X, Dong Z, Wang X, Gao X, Huang M, Yan J, Yang L, Liu Y, Ptacek LJ, Xu Y (2013) Dual roles of FBXL3 in the mammalian circadian feedback loops are important for period determination and robustness of the clock. Proceedings of the National Academy of Sciences of the United States of America 110: 4750-4755

Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, Wu X, Dong Z, Gao X, Liu G, Yang L, Xu Y (2012) The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell death and differentiation 19: 397-405

Wu X, Liu Z, Shi G, Xing L, Wang X, Gu X, Qu Z, Dong Z, Xiong J, Gao X, Zhang C, Xu Y (2011) The circadian clock influences heart performance. Journal of biological rhythms 26: 402-411

Wang X, Tang J, Xing L, Shi G, Ruan H, Gu X, Liu Z, Wu X, Gao X, Xu Y (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function. The EMBO journal 29: 1389-1400

He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL, Jr., Rossner MJ, Nishino S, Fu YH (2009) The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325: 866-870

Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptacek LJ (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell 128: 59-70

Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptacek LJ, Fu YH (2005) Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 434: 640-644

Xu Y, Takeda S, Nakata T, Noda Y, Tanaka Y, Hirokawa N (2002) Role of KIFC3 motor protein in Golgi positioning and integration. J Cell Biol 158: 293-303

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CAM-SU Genomic Resource Center
Email: office@cam-su.org
Phone: 0512-65883573
Address: Suzhou

Copyright: CAM-SU Genomic Resource Center
ICP-SU10229414
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