科研团队 | Research Team

Yulong He (何玉龙), Professor

Professor /Principal Investigator, Cyrus Tang Hematology Center, Soochow University, 2011-present
Courtesy, CAM-SU Genomic Resource Center, 2014-present
Ph.D, Molecular Biology, University of Cambridge, 1999
Email: heyulong@suda.edu.cn

Research Interests

Major goals of our research are to understand the molecular network regulating lymphatic and blood vascular growth and function in health and diseases. Specifically, we have been working on the roles of endothelial receptor tyrosine kinases and their ligands in the regulation of vascular formation, remodeling and homeostasis in development using genetically modified mouse models. In combination of tumor models, we aim to elucidate the role of tumor associated vascular components in tumor progression (Figure: Biological function of VEGFR-3 in lymphatic and blood vascular development).

Representative Publications

1.Shen B#, Shang Z#, Wang B#, Zhang L#, Zhou F#, Li T, Chu M, Jiang H, Wang Y, Qiao T, Zhang J, Sun W, Kong X, He Y*. (2014) Genetic Dissection of TIE Pathway in Lymphatic Maturation and Valve Development. Arterioscler Thromb Vasc Biol. 34:1221-1230

2.Zhang Y, Lu Y, Ma L, Cao X, Xiao J, Chen J, Jiao S, Gao Y, Liu C, Duan Z, Li D, He Y, Wei B, Wang H. (2014) Activation of Vascular Endothelial Growth Factor Receptor-in Macrophages Restrains TLR4-NF-κB Signaling and Protects against Endotoxin Shock. Immunity. 40:501-514.

3.Li T, Yang J, Zhou Q, He Y*. (2012) Molecular Regulation of Lymphangiogenesis in Development and Tumor Microenvironment. Cancer Microenviron. 5:249-260.

4.Lu Y, Xiong Y, Huo Y, Han J, Yang X, Zhang R, Zhu DS, Klein-Heßling S, Li J, Zhang X, Han X, Li Y, Shen B, He Y, Shibuya M, Feng GS, Luo J. (2011) Grb-2-associated Binder 1 (Gab1) Regulates Postnatal Ischemic and Vegf-induced Angiogenesis through the Protein Kinase A-endothelial NOS Pathway. Proc Natl Acad Sci USA. 108:2957-2962.

5.Zhang L#, Zhou F#, Han W#, Shen B, Luo J, Shibuya M, He Y*. (2010) VEGFR-3 Ligand-binding and Kinase Activity are Required for Lymphangiogenesis but not for Angiogenesis. Cell Res. 20:1319-31 Cover paper.

6.Zhou F#, Chang Z#, Zhang L#, Hong Y, Shen B, Wang B, Zhang F, Lu F, Tvorogov D, Alitalo K, Hemmings BA, Yang Z*, He Y*. (2010) Akt / Protein Kinase B is Required for Lymphatic Network Formation, Remodeling and Valve Development. Am J Pathol. 177: 2124-2133.

7.Holopainen T#, Huang H#, Chen C#, Kim KE, Zhang L, Zhou F, Han W, Li C, Yu J, Wu J, Koh GY, Alitalo K*, He Y*. (2009) Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment. Cancer Res. 69:4656-64.

8.Tammela T#, He Y# (cofirst author), Lyytikkä J, Jeltsch M, Markkanen J, Pajusola K, Ylä-Herttuala S, Alitalo K. (2007) Distinct Architecture of Lymphatic Vessels Induced by Chimeric Vascular Endothelial Growth Factor-C/Vascular Endothelial Growth Factor Heparin-Binding Domain Fusion Proteins. Circ Res. 100:1468-75.

9.He Y, Rajantie I, Pajusola K, Jeltsch M, Holopainen T, Yla-Herttuala S, Harding T, Jooss K, Takahashi T, Alitalo K. (2005) VEGFR-3 Mediated Activation of Lymphatic Endothelium is Crucial for Tumor Cell Entry and Spread via Lymphatic Vessels. Cancer Res. 65:4739-46.

10.He Y#, Rajantie I#, Ilmonen M, Makinen T, Karkkainen MJ, Haiko P, Salven P, Alitalo K. (2004) Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis. Cancer Res. 64:3737-40.

11.He Y, Kozaki K, Karpanen T, Koshikawa K, Yla-Herttuala S, Takahashi T, Alitalo K. (2002) Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling. J Natl Cancer Inst.  94:785-7.

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