COVID-19 | COVID-19

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COVID-19

Human ACE2 transgenic model
Description: Human ACE2 is overexpressed using BAC transgene(BAC clone number CH17-203N23, BACPAC). BAC clone is modified with a Venus reporter tag fusing to the N-terminal of ACE2, in order to trace transgene expression in vivo. Primers with 10kb interval coving the whole ACE2 genomic region including ~10kb promoter region are used to screen transgene integration.

Strain Name Allele Type Mouse Sperm Source
C57BL/6N-TgN(Venus-ACE2)/Cmsu Transgene CAM-SU

COVID-19 infection related proteins knockout model
Description: Coronavirus infection require some proteins from the host, including Vim(Vimentin), cell surface transmembrane protease/serine(Tmprss) proteases. We are generating knockout mice for these genes.

Gene Name MGI No. Synonyms ES Cell Mouse Phenotyping
Vim MGI:98932
-
Tmprss2 MGI:1354381
D16Ertd61e, epitheliasin
Tmprss11a MGI:2684853
LOC194597
Tmprss11b MGI:2442893
9930019B18Rik, Tmprss11bnl
Tmprss11c MGI:3521861
-
Tmprss11e MGI:3513175
DESC1
Tmprss11g MGI:2444058
9930032O22Rik, Desc4
Tmprss11f MGI:2442348
4732406D01Rik

联系我们

剑桥-苏大基因组资源中心
电子邮件: office@cam-su.org
地址: 苏州市工业园区仁爱路199号703楼3126室

版权所有: 苏州大学
苏ICP备10229414号-4
备案网址: https://beian.miit.gov.cn/
技术支持: 南京百迈斯信息科技有限公司

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