Ying Xu (徐璎), Professor



Ying Xu (徐璎),  Professor

Director of CAM-SU Genomic Resource Center, 2014-Present

Distinguished Professor, Soochow University, 2014-Present

Distinguished Professor, Model Animal Research Center, Nanjing University, 2006-Present

Postdoctoral Fellow, University of California, San Francisco, 2003-2006

Ph.D., University of Tokyo, 2001

Email: yingxu@suda.edu.cn

RESEARCH INTERESTS

Organisms have adapted to the potent pressures of day-night changes in our environment with daily, anticipatory changes in physiology and behavioral. 

Our laboratory is using cellular, molecular, genetic, evolutional and behavioural approaches to understand the mechanism that drive circadian rhythms in the brain and peripheral tissues and how our daily schedules can disrupt these reliable changes in metabolism, gene expression, Hormone levels and behavior, and result in diseases.

SELECTED PUBLICATIONS

Hirano, A., G. Shi, C.R. Jones, A. Lipzen, L.A. Pennacchio, Y. Xu, W.C. Hallows, T. McMahon, M. Yamazaki,
 L.J. Ptacek, and Y.H. Fu. 2016. A Cryptochrome 2 mutation yields advanced sleep phase in humans. 
Elife. 10.7554/eLife.1669

Qu, Z., H. Zhang, M. Huang, G. Shi, Z. Liu, P. Xie, H. Li, W. Wang, G. Xu, Y. Zhang, L. Yang, G. Huang, 
J.S. Takahashi, W.J. Zhang, and Y. Xu. 2016. Loss of ZBTB20 impairs circadian output and leads to unimodal 
behavioral rhythms. Elife. 5: e17171

Dong, Z., M. Huang, Z. Liu, P. Xie, Y. Dong, X. Wu, Z. Qu, B. Shen, X. Huang, T. Zhang, J. Li, J. Liu, T. Yanase,
C. Zhou, and Y. Xu. 2016. Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell death and differentiation.  doi: 10.1038/cdd.2016.47. [Epub ahead of print]

Shi, G., P. Xie, Z. Qu, Z. Zhang, Z. Dong, Y. An, L. Xing, Z. Liu, Y. Dong, G. Xu, L. Yang, Y. Liu, and 

Y. Xu*. 2016. Distinct Roles of HDAC3 in the Core Circadian Negative Feedback Loop Are Critical for 

Clock Function. Cell reports. 14:823-834.


Wang, Y., A. Stokes, Z. Duan, J. Hui, Y. Xu, Y. Chen, H.W. Chen, K. Lam, and C.J. Zhou. 2016. LDL 

Receptor-Related Protein 6 Modulates Ret Proto-Oncogene Signaling in Renal Development and Cystic 

Dysplasia. Journal of the American  Society of Nephrology : JASN. 27:417-427.


Zhang, L., A. Hirano, P.K. Hsu, C.R. Jones, N. Sakai, M. Okuro, T. McMahon, M. Yamazaki, Y. Xu, N. Saigoh,

K. Saigoh,S.T. Lin, K. Kaasik, S. Nishino, L.J. Ptacek, and Y.H. Fu. 2016. A PERIOD3 variant causes a 

circadian phenotype and is  associated with a seasonal mood trait. Proceedings of the National Academy of

Sciences of the United States of America.

Yan, J., Shi, G., Zhang, Z., Wu, X., Liu, Z., Xing, L., Qu, Z., Dong, Z., Yang, L., Xu, Y. (2014) An intensity ratio of interlocking loops determines circadian period length. Nucleic acids research. 42, 10278-10287.

Liu, Z., Huang, M., Wu, X., Shi, G., Xing, L., Dong, Z., Qu, Z., Yan, J., Yang, L., Panda, S., Xu, Y. (2014) PER1 Phosphorylation Specifies Feeding Rhythm in Mice. Cell Rep. 7(5) 1509-1520.

Wu, X., Wang, B., Dong, Z., Zhou, S., Liu, Z., Shi, G., Cao, Y., Xu, Y. (2013) A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency. Cell Death Dis, 4, e825.

Shi, G., Xing, L., Liu, Z., Qu, Z., Wu, X., Dong, Z., Wang, X., Gao, X., Huang, M., Yan, J., Yang, L., Liu, Y., Ptacek, L., Xu, Y. (2013) Dual roles of FBXL3 in the  mammalian circadian feedback loops are important for period determination and  robustness of the clock. Proceedings of the National Academy of Sciences of the  United States of America. 110, 4750-4755.

Gu, X., Xing, L., Shi, G., Liu, Z., Wang, X., Qu, Z., Wu, X., Dong, Z., Gao, X., Liu, G., Yang, L., Xu, Y. (2012) The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell death and differentiation. 19, 397-405.

Wang, X., Tang, J., Xing, L., Shi, G., Ruan, H., Gu, X., Liu, Z., Wu, X., Gao, X., Xu, Y. (2010) Interaction of MAGED1 with nuclear receptors affects circadian clock function.  The EMBO journal. 29, 1389-1400.

He, Y., Jones, C.R., Fujiki, N., Xu, Y., Guo, B., Holder, JM., Jr., Rossner, Mj., Nishino, S.,  Fu, Y.H. (2009) The Transcriptional Repressor DEC2 Regulates Sleep Length in  Mammals. Science. 325:866-870.

Xu, Y., Padiath, Q.S., Shapiro, R.E., Jones, C.R., Wu, S.C., Saigoh, N., Saigoh, K., Ptacek, L.J., Fu, Y.H. (2005) Functional consequences of a CKIdelta mutation causing familial advanced  sleep phase syndrome. Nature. 434, 640-644.

Xu, Y., Toh, K.L., Jones, C.R., Shin, J.Y., Fu, Y.H. and Ptacek, L.J. (2007) Modeling of a human circadian mutation yields insights into clock regulation by PER2. Cell. 128, 59-70.

Xu, Y., Takeda, S., Nakata, T., Noda, Y., Tanaka, Y. and Hirokawa, N. (2002) Role of KIFC3 motor protein in Golgi positioning and integration. J Cell Biol. 158, 293-303.