Qiaoming Long (龙乔明 ), Professor



Qiaoming Long (龙乔明 ), Professor
Professor, Soochow University, 2014-present
Courtesy, CAM-SU Genomic Resource Center, 2014-present
Ph.D, Roslin Institute, University of Edinburgh, 1996 
Email: qmlong@suda.edu.cn

Research Interests

(1) transcriptional control of cell fate decisions of early pancreatic epithelial cells during mammalian  embryonic development; (2) cellular and molecular mechanisms of hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC); and (3) genetic factors and signaling pathways mediating cellular stress-induced neurodegeneration and cell death in the central nervous system (CNS). Our long-term goal has been to identify novel therapeutic intervention targets and to develop new strategies for more effective prevention and treatment of chronic human diseases, including diabetes mellitus, neurodegenerative diseases, virally and nonvirally induced liver cancers.

Representative Publications

1.Sha, H.B.,  Sun, S.Y., Francisco, A.B., Ehrhardt,  N., Xue, Z., Liu, L., Lawrence, P., Frits Mattijssen, F., Guber, R., Panhwar, M.S.,  Brenna, J.T., Hang Shi, H., Xue, B.Z., Sander Kersten, S., Bensadoun,  A., *Péterfy, M., *Long, Q.M. and *Qi, L. (2014) The ER-associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism.  Cell Metabolism. Sep 2; 20(3): 458-470. (*Co-senior author).

2.Sun, S. Shi, G., Han, X., Francisco, A.B., Ji, Y., Mendonca, N., Liu, X., Locasale, J.W., Simpson, K.W., Duhamel, G.E., Kersten, S., Yates, J.R. 3rd, *Long, Q.M. and *Qi, L. (2014)  Sel1L is Indispensable for Mammalian Endoplasmic Reticulum-associated Degradation, Endoplasmic Reticulum Homeostasis, and Survival. Proc Natl Acad Sci USA. Jan 22. E582-591. (*Co-corresponding author).

3.Qin, L.L, Xu, J., Wu, Z.F., Zhang, Z., Li, J.Q., *Wang, C. and *Long, Q.M. (2013) Notch1-mediated Signaling Regulates Proliferation of Porcine Satellite Cells (PSCs).  Cellular Signaling. 25: 561–569. (*Co-corresponding author).

4.Francisco, A.B., Singh, R., Sha, H., Yan, X., Qi, L., Lei, X.G. and *Long, Q.M. (2011) Haploid Insufficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) Protein Predisposes Mice to High Fat Diet Induced Hyperglycemia. Journal of Biological Chemistry. 286 (24): 21231-21238.  (*Corresponding author).

5.Francisco, A.B., Singh, R., Li, S., Vani, A., Yang, L., Munroe, R.J., Diaferia, G., Cardano, M.,  Biunno, I., Qi, L., Schimenti, J.C. and *Long, Q.M. (2010) Deficiency of Suppressor Enhancer Lin 12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress And Embryonic Lethality.  Journal of Biological Chemistry. 285 (18):13694-13703. (*Corresponding author).

6.Li, S., Francisco, A.B., Han, C., Pattabiraman, S., Foote, M.R., Giesy, S.L., Wang, C., Schimenti, J.C., Boisclair, Y.V. and *Long, Q.M.  (2010) The Full-length Isoform of Pleckstrin Homology Domain-interacting Protein (PHIP) Regulates Postnatal Growth Independently of  Insulin-like Growth Factor 1.  FEBS lett. 584:4121-4127. (*Corresponding author).

7.Li, S., Francisco, A. B., Munroe, R. J., Schimenti, J. C. and *Long, Q.M.  (2010) SEL1L Deficiency Impairs Growth and Differentiation of Pancreatic Epithelial Cells. BMC Developmental Biology.  10:19. (*Corresponding author).

8.Masui, T., Long, Q.M., Beres, T.M., Magnuson, M.A. and MacDonald, R.J. (2007) Early Pancreatic Development Requires the Vertebrate Suppressor of Hairless (RBPJ) in the PTF1 Bhlh Complex. Genes & Development.  21:2629-2643.

9.Long, Q.M., Huang, H., Shafizadeh, E. and Lin, S.  (2000) Stimulation of Erythropoiesis by Inhibiting  a New Hematopoietic Death Receptor in Transgenic Zebrafish.  Nature Cell Biology. 2:549-552.

10.Wang, H., Long, Q.M., Scott, D.M., Sassa, S. and Lin. S.  (1998) A Zebrafish Model for Hepatoerythropoietic Porphyria. Nature Genetics. 20 (3): 239-43. 

11.Long, Q.M., Meng, A.M., Wang, H., Jessen, R.J., Farrell, M. and Lin, S. (1997) GATA-1 Expression Pattern can be Recapitulated in Living Transgenic Zebrafish Using GFP Reporter Gene. Development. 124 (20): 4105-4111.